Tag Archives: NGS

And who made your beer?

Posted on 27 Aug, 2015 by Arun Sethuraman

In the spirit of it being almost Friday, and while we’re on the topic of your favorite beverages – perhaps wine puts you to sleep, couldn’t care less where it came from, but prefer the bitterness of lager beers at your … Continue reading →

Posted in adaptation, evolution, genomics, natural history, next generation sequencing, phylogenetics, population genetics, selection, speciation, yeast | Tagged , , , , | 2 Comments

Who came first – the Paleo- or Native American?

Posted on 23 Jul, 2015 by Arun Sethuraman

In yet another infamous Science vs Nature race, two studies published this Tuesday toss more cans of worms at the ongoing debate about the founding of the Americas – with disparate findings. Uh oh. Skoglund et al. Nature (2015) Genetic … Continue reading →

Posted in genomics, next generation sequencing, Paleogenomics, population genetics | Tagged , , , , | 2 Comments

The brave new world of environmental genomics

Posted on 17 Apr, 2015 by Stacy Krueger-Hadfield

A new special issue of Heredity reflects on the recent advances in environmental genomics (see other posts about eDNA here and here) and highlights the ways NGS can aid in characterizing complex biological systems. The cryptic, as well as the rare but active … Continue reading →

Posted in bioinformatics, Coevolution, DNA barcoding, evolution, genomics | Tagged , , , | 1 Comment

The Ust'-Ishim Genome

Posted on 6 Nov, 2014 by Arun Sethuraman

This year has been monumental in pulling together several interesting pieces in the human evolution out of Africa puzzle (Lazaridis et al., Ruiz-Linares et al., Skoglund et al., Huerta-Sanchez et al., Jeong et al., Pickrell et al., Raghavan et al., … Continue reading →

Posted in genomics, mutation, Paleogenomics, population genetics | Tagged , , | 4 Comments

Dramatically reducing sequencing error via Duplex Tag sequencing

Posted on 2 Oct, 2012 by hollybik

An exciting new study was published in PNAS last month, an open access paper entitled “Detection of ultra-rare mutations by next-generation sequencing”. This new method has the potential to open up a new frontier in Next-gen sequencing bioinformatics, since it allows … Continue reading →

Posted in methods, next generation sequencing | Tagged , , , , | 5 Comments

Riding the Elephant

Posted on 7 Feb, 2011 by Nicholas Crawford

I recently received my first batch of reads from a single paired-end lane run on an [Illumina Hi-Seq](http://www.illumina.com/systems/hiseq_2000.ilmn) instrument. This batch totaled about 20 billion basepairs of DNA sequence, and the associated data files a combined 55.4 gigs of text. … Continue reading →

Posted in bioinformatics, next generation sequencing, software | Tagged , , , , | 9 Comments