Category Archives: software

Sweptaway – Part 2

Posted on 17 Sep, 2015 by Arun Sethuraman

Numerous methods have been developed over the last few years for the detection of selective sweeps (hard and soft – see my previous post). This week, we look at three new studies that (a) compare existing methods to detect sweeps … Continue reading →

Posted in adaptation, bioinformatics, evolution, genomics, methods, population genetics, selection, software, theory | Tagged , , , | Leave a comment

Where's your wine from?

Posted on 20 Aug, 2015 by Arun Sethuraman

Human-mediated selection of yeast cultures has played a huge role in the development of numerous unique strains of Sacchromyces cerevisiae, often attributed to production of a wide variety of wines the world over. Previous studies have indicated a single domesticated … Continue reading →

Posted in domestication, evolution, genomics, horizontal gene transfer, microbiology, Molecular Ecology, the journal, next generation sequencing, phylogenetics, phylogeography, population genetics, STRUCTURE, yeast | Tagged , , , | 1 Comment

Models matter when linking genetic diversity to niche model predictions

Posted on 13 Aug, 2015 by Rob Denton

Ecological niche models and the methods to create them continue to evolve. These techniques provide a tidy way to relate the distributions of taxa to environmental variables from the present, past, or future. Oh, and they are pretty too: Those pretty … Continue reading →

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PCA of multilocus genotypes in R

Posted on 30 Jul, 2015 by Arun Sethuraman

An earlier post from Mark Christie showed up on my feed on calculating allele frequencies from genotypic data in R, and I wanted to put together a quick tutorial on making PCA (Principal Components Analysis) plots using genotypes. I used … Continue reading →

Posted in bioinformatics, genomics, howto, population genetics, R, software | Tagged , , | 6 Comments

What do with all those pesky mtDNA reads in your NGS experiment

Posted on 21 Jul, 2015 by Noah Snyder-Mackler

Have you ever noticed how many reads from your high throughput sequencing project map to the tiny fraction of your genome that is the mitochondrial genome (mtDNA)? Pretty much any NGS experiment (e.g., RNA-seq, DNA-seq, capture-based sequencing) leave you with … Continue reading →

Posted in bioinformatics, genomics, howto, mutation, software, Uncategorized | Tagged , | Leave a comment

IMa2p – Parallel Isolation with Migration Analyses

Posted on 16 Jul, 2015 by Arun Sethuraman

I figured that it was time to write an update on my post from a year ago on Bayesian MCMC in inferring ancestral demography. Recently, my postdoctoral advisor, Jody Hey and I released a version of the popular IMa2 program, … Continue reading →

Posted in bioinformatics, genomics, howto, software, theory | Tagged , , , , , | 1 Comment

Mixed modeling of methylation measures (increase your power by 60%)

Posted on 7 Jul, 2015 by Noah Snyder-Mackler

Do you want to increase your power to detect differentially methylated CpG sites by 60%*? Yes?! Then do I have the pre-print for you.

Posted in bioinformatics, genomics, methods, next generation sequencing, software | Tagged , , | 1 Comment

marmap

Posted on 3 Jul, 2015 by Stacy Krueger-Hadfield

A couple years ago, Benoit Simon-Bouhet ended up sharing an office with Eric Pante, then a post-doc fellow in his former lab. The two quickly realized they were in a lab in which few people had the expertise or taste for coding. Thus, on … Continue reading →

Posted in community ecology, conservation, evolution, howto, natural history, R, software | Tagged , , , , | Leave a comment

IBE/IBD Contour plots in R

Posted on 18 Jun, 2015 by Arun Sethuraman

Rob’s post from yesterday motivated me to find an alternate way of visualizing correlations between matrices of geographical or ecological data, and genetic data. I have seen plenty of Mantel, or partial Mantel tests of correlation, as well as plots … Continue reading →

Posted in bioinformatics, howto, population genetics, R, software | Tagged , , , | 5 Comments

Procrustes Analyses in R

Posted on 23 Apr, 2015 by Arun Sethuraman

Procrustes transformations (i.e. a form of multidimensional scaling that allows the comparison of two data sets) have been used extensively in recent literature to assess the similarity of geographical and genetic distributions of species, following the lead of Wang et … Continue reading →

Posted in genomics, howto, population genetics, R, software | Tagged , , , | 3 Comments