Category Archives: population genetics

Ice-Age Euro-trips

Recent works that attempt to get at human migrations inside Europe paint a complex portrait of migratory events, admixture with archaic hominids, and adaptive evolution to new geographies, and a changing global climate. Analyzing whole genomes of 51 ancient humans … Continue reading

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Opening Pandora's box: PSMC and population structure

Essentially, all models are wrong, but some are useful. — George Box Publication of the Li and Durbin’s 2011 paper titled “Inference of human population history from individual whole-genome sequences” was a milestone in the inference of demography. By allowing … Continue reading

Posted in bioinformatics, methods, Paleogenomics, population genetics, theory | Tagged , , , , | 6 Comments

RADseq and missing data: some considerations

Unlike Sanger sequencing, where loci are directly targeted for each individual and sequencing errors are relatively rare, massively multilocus datasets from next generation sequencing platforms are characterized by large amounts of missing data. This is particularly true for restriction digest … Continue reading

Posted in bioinformatics, genomics, methods, Molecular Ecology, the journal, next generation sequencing, phylogenetics, population genetics, theory | Tagged , , , | 6 Comments

On Integrative Species Delimitation…

Accurate delimitation of species is a fundamental first step that underlies much of what we do in biology. But this can prove challenging in many situations. Why? Let me count the ways. Incomplete lineage sorting, hybridization, morphological conservatism, and niche … Continue reading

Posted in evolution, methods, phylogeography, population genetics, software, species delimitation | 1 Comment

Signatures of the reproductive lottery

In marine populations, effective population sizes are usually several orders of magnitude lower than the census size. This difference is thought to be driven by high fecundity, variation in reproductive success and pronounced early mortality, resulting in genetic drift across generations. In … Continue reading

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What does the island fox say?

Small populations are characterized by large drift and reduced efficacy of selection effects, which result in fixation of both advantageous and deleterious alleles, accumulation of homozygosity, and often reduction in population fitness. What with plummeting mammal populations across biota, understanding … Continue reading

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Disentangling the wolf-coyote admixture through an ancestry-based approach

Large carnivores like bears and wolves still pose a puzzle for systematics and population genetics. The more data we get, the more complex their evolutionary history seems to be.

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Analysis of the human microbiome reveals you are (at least related to) what you eat, in a manner of speaking

Understanding microbial symbioses, and more specifically how the human microbiome affects our health, is currently a hot topic in the land of microbiology and metagenomics. The most recent special edition of Science focuses on reviews and articles centered on understanding … Continue reading

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Sweeps and Demographic Inference

Population genetics presents us with numerous conundrums – several of which have to do with how the same genomic disposition can be “reached” over evolutionary time with multiple alternate demographic or selective processes. I have discussed several of these issues … Continue reading

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hyRAD and museum genomics

While the RAPTURE may have arrived, the development of novel restriction digest-based library prepartation techniques — and portmanteaus — continues unabated. In a paper published in PLoS ONE last month (and previously available as a preprint on bioRxiv), Tomasz Suchan … Continue reading

Posted in genomics, methods, natural history, next generation sequencing, phylogenetics, phylogeography, population genetics | Tagged , , , , , | 3 Comments